Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model
Identifieur interne : 000114 ( Main/Exploration ); précédent : 000113; suivant : 000115Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model
Auteurs : Mitsuaki Ono [Japon] ; Masamitsu Oshima [Japon] ; Miho Ogawa [Japon] ; Wataru Sonoyama [Japon] ; Emilio Satoshi Hara [Japon] ; Yasutaka Oida [Japon] ; Shigehiko Shinkawa [Japon] ; Ryu Nakajima [Japon] ; Atsushi Mine [Japon] ; Satoru Hayano [Japon] ; Satoshi Fukumoto [Japon] ; Shohei Kasugai [Japon] ; Akira Yamaguchi [Japon] ; Takashi Tsuji [Japon] ; Takuo Kuboki [Japon]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation
Url:
DOI: 10.1038/srep44522
PubMed: 28300208
PubMed Central: 5353657
Affiliations:
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xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oshima, Masamitsu" sort="Oshima, Masamitsu" uniqKey="Oshima M" first="Masamitsu" last="Oshima">Masamitsu Oshima</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Research Institute for Science and Technology, Tokyo University of Science</institution>, Noda, Chiba, 278-8510,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>RIKEN Center for Developmental Biology</institution>, Kobe, Hyogo, 650-0047,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ogawa, Miho" sort="Ogawa, Miho" uniqKey="Ogawa M" first="Miho" last="Ogawa">Miho Ogawa</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Research Institute for Science and Technology, Tokyo University of Science</institution>, Noda, Chiba, 278-8510,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>RIKEN Center for Developmental Biology</institution>, Kobe, Hyogo, 650-0047,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Organ Technologies Inc.</institution>, Tokyo, 105-0001,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sonoyama, Wataru" sort="Sonoyama, Wataru" uniqKey="Sonoyama W" first="Wataru" last="Sonoyama">Wataru Sonoyama</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hara, Emilio Satoshi" sort="Hara, Emilio Satoshi" uniqKey="Hara E" first="Emilio Satoshi" last="Hara">Emilio Satoshi Hara</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oida, Yasutaka" sort="Oida, Yasutaka" uniqKey="Oida Y" first="Yasutaka" last="Oida">Yasutaka Oida</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shinkawa, Shigehiko" sort="Shinkawa, Shigehiko" uniqKey="Shinkawa S" first="Shigehiko" last="Shinkawa">Shigehiko Shinkawa</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nakajima, Ryu" sort="Nakajima, Ryu" uniqKey="Nakajima R" first="Ryu" last="Nakajima">Ryu Nakajima</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mine, Atsushi" sort="Mine, Atsushi" uniqKey="Mine A" first="Atsushi" last="Mine">Atsushi Mine</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry</institution>, Yamadaoka, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayano, Satoru" sort="Hayano, Satoru" uniqKey="Hayano S" 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transplantation in a postnatal canine model</title><author><name sortKey="Ono, Mitsuaki" sort="Ono, Mitsuaki" uniqKey="Ono M" first="Mitsuaki" last="Ono">Mitsuaki Ono</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oshima, Masamitsu" sort="Oshima, Masamitsu" uniqKey="Oshima M" first="Masamitsu" last="Oshima">Masamitsu Oshima</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Research Institute for Science and Technology, Tokyo University of Science</institution>, Noda, Chiba, 278-8510,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>RIKEN Center for Developmental Biology</institution>, Kobe, Hyogo, 650-0047,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ogawa, Miho" sort="Ogawa, Miho" uniqKey="Ogawa M" first="Miho" last="Ogawa">Miho Ogawa</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Research Institute for Science and Technology, Tokyo University of Science</institution>, Noda, Chiba, 278-8510,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>RIKEN Center for Developmental Biology</institution>, Kobe, Hyogo, 650-0047,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Organ Technologies Inc.</institution>, Tokyo, 105-0001,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sonoyama, Wataru" sort="Sonoyama, Wataru" uniqKey="Sonoyama W" first="Wataru" last="Sonoyama">Wataru Sonoyama</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hara, Emilio Satoshi" sort="Hara, Emilio Satoshi" uniqKey="Hara E" first="Emilio Satoshi" last="Hara">Emilio Satoshi Hara</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oida, Yasutaka" sort="Oida, Yasutaka" uniqKey="Oida Y" first="Yasutaka" last="Oida">Yasutaka Oida</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shinkawa, Shigehiko" sort="Shinkawa, Shigehiko" uniqKey="Shinkawa S" first="Shigehiko" last="Shinkawa">Shigehiko Shinkawa</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nakajima, Ryu" sort="Nakajima, Ryu" uniqKey="Nakajima R" first="Ryu" last="Nakajima">Ryu Nakajima</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mine, Atsushi" sort="Mine, Atsushi" uniqKey="Mine A" first="Atsushi" last="Mine">Atsushi Mine</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry</institution>, Yamadaoka, Suita, Osaka 565-0871,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayano, Satoru" sort="Hayano, Satoru" uniqKey="Hayano S" first="Satoru" last="Hayano">Satoru Hayano</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fukumoto, Satoshi" sort="Fukumoto, Satoshi" uniqKey="Fukumoto S" first="Satoshi" last="Fukumoto">Satoshi Fukumoto</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Division of Pediatric Dentistry, Tohoku University Graduate School of Dentistry</institution>, Sendai, Miyagi, 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kasugai, Shohei" sort="Kasugai, Shohei" uniqKey="Kasugai S" first="Shohei" last="Kasugai">Shohei Kasugai</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Section of Oral Implantology and Regenerative Dental Medicine, Graduate School of Tokyo Medical and Dental University</institution>, Bunkyo-ku, Tokyo, 113-8549,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yamaguchi, Akira" sort="Yamaguchi, Akira" uniqKey="Yamaguchi A" first="Akira" last="Yamaguchi">Akira Yamaguchi</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Section of Oral Pathology, Department of Oral Restitution, Graduate School of Tokyo Medical and Dental University</institution>, Chiyoda-ku, Tokyo, 113-8549,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Oral Health Science Center, Tokyo Dental College</institution>, Chiyoda-ku, Tokyo, 101-0061,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tsuji, Takashi" sort="Tsuji, Takashi" uniqKey="Tsuji T" first="Takashi" last="Tsuji">Takashi Tsuji</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Research Institute for Science and Technology, Tokyo University of Science</institution>, Noda, Chiba, 278-8510,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>RIKEN Center for Developmental Biology</institution>, Kobe, Hyogo, 650-0047,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Organ Technologies Inc.</institution>, Tokyo, 105-0001,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kuboki, Takuo" sort="Kuboki, Takuo" uniqKey="Kuboki T" first="Takuo" last="Kuboki">Takuo Kuboki</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University</institution>, Okayama, 700-8525,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation <italic>in vitro</italic>. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to human medicine is required to demonstrate tooth restoration by reconstructing bioengineered tooth germ using a postnatal large-animal model. Herein, we demonstrate functional tooth restoration through the autologous transplantation of bioengineered tooth germ in a postnatal canine model. The bioengineered tooth, which was reconstructed using permanent tooth germ cells, erupted into the jawbone after autologous transplantation and achieved physiological function equivalent to that of a natural tooth. This study represents a substantial advancement in whole-organ replacement therapy through the transplantation of bioengineered organ germ as a practical model for future clinical regenerative medicine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Proffit, W R" uniqKey="Proffit W">W. R. Proffit</name></author><author><name sortKey="Fields, H W" uniqKey="Fields H">H. W. Fields</name></author><author><name sortKey="Sarver, D M" uniqKey="Sarver D">D. M. Sarver</name></author><author><name sortKey="John, D" uniqKey="John D">D. John</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avery, J K" uniqKey="Avery J">J. K. Avery</name></author><author><name sortKey="Steele, P F" uniqKey="Steele P">P. F. Steele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dawson, P E" uniqKey="Dawson P">P. E. 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